S-Ruxolitinib (INCB018424)

Product Name: S-Ruxolitinib (INCB018424)
CAS No.: 941685-37-6
Chemical Name: S-Ruxolitinib (INCB018424)
Synonyms: CS-1401;INCB 18424;S-INCB18424;S-Ruxolitinib;Ruxolitinib Impurity A;S-Ruxolitinib (INCB018424);Ruxolitinib (S enantioMer);RUXOLITINIB S ENANTIOMER;INCB18424;S-Ruxolitinib INCB018424 INCB-018424;Ruxolitinib Impurity 1（(S)-Ruxolitinib）
CBNumber: CB82665159
Molecular Formula: C17H18N6
Formula Weight: 306.36
MOL File: 941685-37-6.mol

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S-Ruxolitinib (INCB018424) Property

Melting point:: 138-143oC
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 11.63±0.50(Predicted)
color: White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C988940
Product name: (3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile(ent-Ruxolitinib)
Packaging: 100mg
Price: $1465
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb154739
Product name: S-Ruxolitinib (INCB018424)
Purity: >98%
Packaging: 1g
Price: $1802
Updated: 2021/12/16

ChemScene

Product number: CS-2768
Product name: Ruxolitinib(Senantiomer)
Purity: 99.92%
Packaging: 5mg
Price: $72
Updated: 2021/12/16

ChemScene

Product number: CS-2768
Product name: Ruxolitinib(Senantiomer)
Purity: 99.92%
Packaging: 10mg
Price: $84
Updated: 2021/12/16

ChemScene

Product number: CS-2768
Product name: Ruxolitinib(Senantiomer)
Purity: 99.92%
Packaging: 50mg
Price: $144
Updated: 2021/12/16

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S-Ruxolitinib (INCB018424) Chemical Properties,Usage,Production

Uses

(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile is a newly developed JAK2 inhibitor therapy aimed to improve MPN-associated splenomegaly and systemic symptoms. The opposite enantiomer of Ruxolitinib (R702000).

Biological Activity

s-ruxolitinib is the chirality of incb018424, is a potent and selective small-molecule janus kinase 1 (jak1) and jak2 inhibitor. it was initially developed to target the constitutive activation of the jak-stat pathway. janus kinases (jaks) are a family of cytoplasmic tyrosine kinases that mediates signals from the receptors for various cytokines and growth factors that have a key role in haematopoiesis and immune function. ruxolitinib maintains its anti-jak activity by competitive inhibition of the atp-binding catalytic site of the kinase domain. ruxolitinib is well absorbed at >95%. exposure of jak2v617f-positive ba/f3 cells to ruxolitinib iss shown to result in reduced cellular proliferation.ruben a. mesa, uma yasothan, peter kirkpatrick. ruxolitinib. nature reviews drug discovery. 2012; 11: 103-104john mascarenhas, ronald hoffman. ruxolitinib: the first fda approved therapy for the treatment of myeloﬁbrosis. clinical cancer research. 2012; 18(11): 3008 - 3014

target

JAK1

S-Ruxolitinib (INCB018424) Preparation Products And Raw materials

Raw materials

Preparation Products

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S-Ruxolitinib (INCB018424) Suppliers

Canada 1 China 94 India 2 United States 13 Global 110

ApexBio Technology LLC

Tel: +1-832-696-8203
Fax: +1-832-641-3177
Email: info@apexbt.com
Country: United States
ProdList: 477
Advantage: 60

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Standardpharm Co. Ltd.

Tel: 86-714-3992388
Email: overseasales1@yongstandards.com
Country: United States
ProdList: 14336
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

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View Lastest Price from S-Ruxolitinib (INCB018424) manufacturers

Career Henan Chemical Co

Product: S-Ruxolitinib(INCB018424) 941685-37-6
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: g/kg/T
Release date: 2019-12-18

941685-37-6, S-Ruxolitinib (INCB018424)Related Search:

Ruxolitinib phosphate 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile Ruxolitinib 1H-Pyrazole-1-propanenitrile, 4-(6-amino-5-formyl-4-pyrimidinyl)-β-cyclopentyl-, (βR)- Cabozantinib Zanubrutinib Lapatinib Erlotinib Sunitinib Dasatinib LOXO-292 Tofacitinib Selonsertib Bortezomib ABT-199 Linsitinib VE 822 GDC-0879

S-Ruxolitinib (INCB018424)

S-Ruxolitinib

INCB 18424

1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βS)-

Ruxolitinib (S enantioMer)

(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl]propanenitrile

RUXOLITINIB S ENANTIOMER;INCB18424

(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (ent-Ruxolitinib)

CS-1401

Ruxolitinib Impurity 1（(S)-Ruxolitinib）

(S)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile

Ruxolitinib Impurity A

"(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile"Q: What is "(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile" Q: What is the CAS Number of "(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile" Q: What is the storage condition of "(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile"

S-Ruxolitinib INCB018424 INCB-018424

S-INCB18424

941685-37-6

Inhibitor

Inhibitors

Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals

JAK

STAT